DNA Moiré Superlattices are the focus of a study now published in Nature Nanotechnology. Credit: University of Stuttgart / 2nd Physics Institute
In a stunning leap forward, scientists have engineered DNA
DNA, or deoxyribonucleic acid, is a molecule made of two long strands of nucleotides twisted into a double helix. It serves as the hereditary material in humans and nearly all other organisms, encoding the genetic instructions used for development, functioning, and reproduction. Most DNA resides in the cell nucleus (nuclear DNA), while a smaller portion is found in mitochondria (mitochondrial DNA or mtDNA).
” data-gt-translate-attributes=”[{"attribute":"data-cmtooltip", "format":"html"}]” tabindex=”0″ role=”link”>DNA to act as a molecular architect, building intricate moiré superlattices with unprecedented control.
By programming twist angles and geometric patterns directly into DNA strands, researchers have created self-assembling nanostructures that could revolutionize everything from optics to quantum materials. These DNA-built lattices form on their own in solution, no manual stacking required, opening doors to materials that guide light, filter spin, or vibrate in precisely tuned ways — all at the
nanoscale
The term "nanoscale" refers to dimensions that are measured in nanometers (nm), with one nanometer equaling one-billionth of a meter. This scale encompasses sizes from approximately 1 to 100 nanometers, where unique physical, chemical, and biological properties emerge that are not present in bulk materials. At the nanoscale, materials exhibit phenomena such as quantum effects and increased surface area to volume ratios, which can significantly alter their optical, electrical, and magnetic behaviors. These characteristics make nanoscale materials highly valuable for a wide range of applications, including electronics, medicine, and materials science.
Moiré superlattices are now a key focus in cutting-edge research across condensed matter physics and photonics. Yet building these structures usually requires a painstaking process, involving highly accurate layer alignment and transfer techniques performed under controlled laboratory conditions.
“Our approach bypasses traditional constraints of creating moiré superlattices,” says Prof. Laura Na Liu, director of the 2nd Physics Institute at the University of Stuttgart.
A Self-Assembling Blueprint for Nanoscale Structures
“Unlike conventional methods that rely on mechanical stacking and twisting of two-dimensional materials, our platform leverages a bottom-up assembly process,” explains Laura Na Liu. The assembly process refers to the linking of individual DNA strands to form larger, ordered structures. The process is guided by self-organization, meaning the DNA strands link together on their own through molecular interactions, without any outside intervention.
The Stuttgart team has built their method around this principle. “We encode the geometric parameters of the superlattice – such as rotation angle, sublattice spacing, and lattice symmetry – directly into the molecular design of the initial structure, known as the nucleation seed. We then allow the entire architecture to self-assemble with nanometer precision.”
This nucleation seed acts as a molecular instruction manual, guiding the growth of two-dimensional DNA lattices into carefully twisted bilayers or trilayers. The entire process takes place in a single step within a liquid solution, without the need for complex manipulation.
Stuttgart team (from left to right): Prof. Laura Na Liu, Dr. Xinxin Jing, Dr. Tobias Heil, and Prof. Peter A. van Aken. Credit: University of Stuttgart / 2nd Physics Institute
Unlocking the Intermediate Nanometer Realm
While moiré superlattices have been widely explored at the atomic (angstrom) and photonic (submicron) scales, the intermediate nanometer regime, where both molecular programmability and material functionality converge, has remained largely inaccessible. The Stuttgart researchers have closed this gap with their current study. The team combines two powerful DNA nanotechniques: DNA origami and single-stranded tile (SST) assembly.
Using this hybrid strategy, the researchers constructed micrometer-scale superlattices with unit cell dimensions as small as 2.2 nanometers, featuring tunable twist angles and various lattice symmetries, including square, kagome, and honeycomb. They also demonstrated gradient moiré superlattices, in which the twist angle and hence moiré periodicity varies continuously across the structure. “These superlattices reveal well-defined moiré patterns under transmission electron microscopy, with observed twist angles closely matching those encoded in the DNA origami seed,” notes co-author Prof. Peter A. van Aken from the Max Planck Institute for Solid State Research.
The study also introduces a new growth process for moiré superlattices. The process is initiated by spatially defined capture strands on the DNA seed that act as molecular ‘hooks’ to precisely bind SSTs and direct their interlayer alignment. This enables the controlled formation of twisted bilayers or trilayers with accurately aligned SST sublattices.
Powerful Applications from Optics to Spintronics
Their high spatial resolution, precise addressability, and programmable symmetry endow the new moiré superlattices with significant potential for diverse applications in research and technology. For example, they are ideal scaffolds for nanoscale components – such as fluorescent molecules, metallic nanoparticles or semiconductors
Semiconductors are materials with electrical conductivity that falls between conductors and insulators, making them essential for modern electronics. They are typically crystalline solids, the most common of which is silicon, used extensively in the production of electronic components such as transistors and diodes. Semiconductors are unique because their conductivity can be altered and controlled through doping—adding impurities to the material to change its electrical properties. This property allows them to serve as the foundation for integrated circuits and microchips, powering everything from computers and smartphones to advanced medical devices and renewable energy technologies. The behavior of semiconductors is also crucial in the development of various electronic, photonic, and quantum devices.
” data-gt-translate-attributes=”[{"attribute":"data-cmtooltip", "format":"html"}]” tabindex=”0″ role=”link”>semiconductors in customized 2D and 3D architectures.
When chemically transformed into rigid frameworks, these lattices could be repurposed as phononic crystals or mechanical metamaterials
Metamaterials are engineered structures with properties not found in naturally occurring materials, especially in how they interact with electromagnetic waves. Their unique design allows them to bend, absorb, or manipulate light and sound in unusual ways, enabling applications like invisibility cloaks, advanced lenses, and antenna enhancements.
” data-gt-translate-attributes=”[{"attribute":"data-cmtooltip", "format":"html"}]” tabindex=”0″ role=”link”>metamaterials with tunable vibrational responses. Their spatial gradient design also opens avenues for transformation optics and gradient-index photonic devices, where moiré periodicity could steer light or sound along controlled trajectories.
One particularly promising application lies in spin-selective electron transport. DNA has been shown to act as a spin filter, and these well-ordered superlattices with defined moiré symmetries could serve as a platform to explore topological spin transport phenomena in a highly programmable setting.
“This is not about mimicking quantum materials,” says Laura Na Liu. “It’s about expanding the design space and making it possible to build new types of structured matter from the bottom up, with geometric control embedded directly into the molecules.”
Reference: “DNA moiré superlattices” by Xinxin Jing, Nicolas Kroneberg, Andreas Peil, Benjamin Renz, Longjiang Ding, Tobias Heil, Katharina Hipp, Peter A. van Aken, Hao Yan and Na Liu, 17 July 2025, Nature Nanotechnology. DOI: 10.1038/s41565-025-01976-3
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